Irresistible Spicy Southern Chicken Spaghetti Casserole

Name: Irresistible Spicy Southern Chicken Spaghetti Casserole
Prep time: 15 min
Cook time: 30 min
Total time: 45 min
Yield: 6.0
Ingredients: 2 cups cooked spaghetti; 2 cups shredded cooked chicken; 1 cup diced tomatoes; 1 cup heavy cream; 1 cup shredded cheese; 1 tablespoon Cajun seasoning; Salt and pepper to taste

Highlighted under: Comfort Food

Treat your family to a comforting and flavorful meal with this Irresistible Spicy Southern Chicken Spaghetti Casserole. Packed with tender chicken, zesty seasonings, and creamy sauce, this casserole is a delightful twist on classic comfort food. Perfect for weeknight dinners or gatherings, you’ll love the way the spices elevate the rich flavors.

Created by

Talia Preston

Last updated on 2025-11-26T17:07:19.811Z

This recipe is a family favorite, bringing everyone together around the dinner table. It's the perfect blend of spices and creaminess that makes it irresistible!

A Comforting Family Favorite

There's something truly special about a casserole that brings the whole family together. The Irresistible Spicy Southern Chicken Spaghetti Casserole is one of those dishes that creates a warm, inviting atmosphere around the dinner table. Not only is it satisfying, but it also allows for versatile variations, ensuring everyone can enjoy it according to their tastes.

Whether you're serving it at a cozy family dinner or a lively gathering with friends, this casserole is bound to be a hit. Its combination of flavors and textures keeps every bite interesting, making it a standout dish that will have your loved ones asking for seconds.

The Flavor Profile

What sets this casserole apart is its robust flavor profile. The use of Cajun seasoning infuses the dish with a delightful kick that elevates the traditional comfort food experience. Combined with the creaminess of the heavy cream and the richness of the shredded chicken, each ingredient plays a crucial role in creating a harmonious symphony of flavors.

The diced tomatoes lend a fresh, tangy note that balances the richness of the other ingredients, while the layer of melted cheese on top adds a beautiful golden crust. This marriage of flavors not only tastes amazing but also fills your kitchen with an irresistible aroma as it bakes.

Perfect for Any Occasion

One of the best things about the Irresistible Spicy Southern Chicken Spaghetti Casserole is its versatility. It works beautifully for casual family dinners, but it's also impressive enough to serve at festive gatherings. You can easily double or even triple the recipe to accommodate larger groups, making it an ideal choice for potlucks and celebrations.

Additionally, this dish can be prepared ahead of time, allowing busy families to enjoy a home-cooked meal without the stress of last-minute cooking. Just assemble your casserole, refrigerate it, and pop it in the oven when you're ready to feast.

Ingredients

For the Casserole

2 cups cooked spaghetti
2 cups shredded cooked chicken
1 cup diced tomatoes
1 cup heavy cream
1 cup shredded cheese
1 tablespoon Cajun seasoning
Salt and pepper to taste

Mix all ingredients in a large bowl before assembling the casserole.

Instructions

Preheat the Oven

Preheat your oven to 350°F (175°C).

Combine Ingredients

In a large bowl, mix together the cooked spaghetti, shredded chicken, diced tomatoes, heavy cream, Cajun seasoning, and half of the cheese.

Transfer to Baking Dish

Pour the mixture into a greased baking dish and top with the remaining cheese.

Bake

Bake in the preheated oven for 25-30 minutes or until the cheese is bubbly and golden brown.

Let cool for a few minutes before serving. Enjoy!

Tips for Success

To ensure your casserole turns out perfectly, make sure that your spaghetti is cooked al dente before mixing it with the other ingredients. This helps prevent the pasta from becoming mushy during baking, preserving the texture of your dish.

Don't hesitate to customize the recipe to suit your preferences. For instance, you can add sautéed bell peppers or jalapeños for an extra kick, or try different cheeses like pepper jack for added spice.

Serving Suggestions

When serving your casserole, consider pairing it with a fresh salad or some garlic bread to round out the meal. A crisp green salad with a lemon vinaigrette contrasts beautifully with the rich flavors of the casserole, providing a refreshing balance.

For a complete meal experience, you can also serve it with a homemade coleslaw or some roasted vegetables. These sides complement the richness of the casserole while adding more nutritional variety to your dinner.

Storage and Reheating

Leftovers can be stored in an airtight container in the refrigerator for up to three days. This makes it a convenient option for meal prepping or taking for lunch the next day. Just reheat in the microwave or oven until heated through.

If you're not planning to eat it all right away, you can also freeze the casserole before baking. Cover it tightly with foil or plastic wrap and store it in the freezer for up to three months. When you're ready to bake it, just thaw in the fridge overnight and follow the baking instructions as usual.

Questions About Recipes

→ Can I use leftover chicken for this recipe?

Yes, leftover chicken works great and saves time!

→ How can I make this dish spicier?

Add more Cajun seasoning or some chopped jalapeños for an extra kick.